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Recombinant A(H6N1)-H274Y avian influenza virus with dual drug resistance does not require permissive mutations to retain the replicative fitness in vitro and in ovo.

Virology - 1 Feb 2024

Bialy Dagmara, Richardson Samuel, Chrzastek Klaudia, Bhat Sushant, Polo Noemi, Freimanis Graham, Iqbal Munir, Shelton Holly

Abstract excerpt

The possible emergence of drug-resistant avian flu raises concerns over the limited effectiveness of currently approved antivirals (neuraminidase inhibitors - NAIs) in the hypothetical event of a zoonotic spillover. Our study demonstrated that the recombinant avian A(H6N1) viruses showed reduced inhibition (RI) by multiple NAI drugs following the introduction of point mutations found predominantly in the...

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PMID: 38086284
DOI: 10.1016/j.virol.2023.109954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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