[Enzymatic mechanisms of compensation of deleterious mutations].

Article

[Enzymatic mechanisms of compensation of deleterious mutations].

Molekuliarnaia biologiia - 1 Jan 2000

Vol'kenshteĭn M V, Gol'dshteĭn B N

Abstract excerpt

Mechanisms of stabilization and compensation, that occur in biochemical systems with enzymes modified by harmful mutations are considered. The compensation of such mutations can result in their evolutionary neutralism. The stabilization is considered due to kinetic signals of metabolites which fo...

Topics

Animals
Biological Evolution
Enzymes
Kinetics
Models, Genetic
Multienzyme Complexes
Mutation
Protein Conformation

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