Article
[Enzymatic mechanisms of compensation of deleterious mutations].
Molekuliarnaia biologiia - 1 Jan 2000
Vol'kenshteĭn M V, Gol'dshteĭn B N
Abstract excerpt
Mechanisms of stabilization and compensation, that occur in biochemical systems with enzymes modified by harmful mutations are considered. The compensation of such mutations can result in their evolutionary neutralism. The stabilization is considered due to kinetic signals of metabolites which form the direct and feedback connections with enzymes (temporal stabilization), and also the compensation in enzymatic...
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