Back to search

Article

A general hypothesis of multistable systems in pathophysiology

2022-09-30

Abstract excerpt

Despite intensive investigations numerous diseases remain etiologically puzzling and recalcitrant to treatments. A hypothesis is proposed here assuming that these difficulties are due to an unsuitable approach to the mechanisms of life, which is subjugated by an apparent complexity and fails to grasp the uniformity that lays behind. The stability of metabolism, despite the enormous complex of chemical reactions, s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
17dd6860-466b-5173-8f8a-f3fcd0b3ab52
DOI
10.12688/f1000research.123183.3
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A general hypothesis of multistable systems in pathophysiologyDOI 10.12688/f1000research.123183.3
Homeostasis - Resiliance and SusceptibilitySemantic proximity
Systems biology of eukaryotic superorganisms and the holobiont concept.Semantic proximity
The nature of diseases: evolutionary, thermodynamic and historical aspects.Semantic proximity
The Paradigm-Shift toward the Next Generation of DrugsSemantic proximity
Proteolethargy is a pathogenic mechanism in chronic diseaseSemantic proximity
Multistability: a major means of differentiation and evolution in biological systems.Semantic proximity
Vigor of survival determinism: subtle evolutionary gradualism interspersed with robust phylogenetic leaping.Semantic proximity
Phenotypic flexibility as key factor in the human nutrition and health relationshipSemantic proximity
A multistationary loop model of ALS unveils critical molecular interactions involving mitochondria and glucose metabolism.Semantic proximity
Bistability in macrophage polarization and metabolic implicationsSemantic proximity
A bistable circuit regulates miRNA-155 levels in human macrophage inflammatory transitionsSemantic proximity
Self-organized living systems: conjunction of a stable organization with chaotic fluctuations in biological space-time.Semantic proximity
Select a neighboring publication to make it the new centre.