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Article

NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease.

Biochimica et biophysica acta. Molecular basis of disease - 1 Feb 2024

Caria Inês, Nunes Maria João, Ciraci Viviana, Carvalho Andreia Neves, Ranito Catarina, Santos Susana G, Gama Maria João, Castro-Caldas Margarida, Rodrigues Cecília M P, Ruas Jorge L, Rodrigues Elsa

Abstract excerpt

Disruption of brain cholesterol homeostasis has been implicated in neurodegeneration. Nevertheless, the role of cholesterol in Parkinson's Disease (PD) remains unclear. We have used N2a mouse neuroblastoma cells and primary cultures of mouse neurons and 1-methyl-4-phenylpyridinium (MPP+), a known mitochondrial complex I inhibitor and the toxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38061599
DOI: 10.1016/j.bbadis.2023.166980

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