Machine learning and molecular subtype analyses provide insights into PANoptosis-associated genes in rheumatoid arthritis

Abstract excerpt

BACKGROUND: PANoptosis represents a newly identified form of programmed cell death that plays a significant role in the autoimmune diseases. Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies. Nevertheless, the specific biomarkers and molecular mechanisms responsible for the apoptotic characteristics of RA remain largely uninvestigated. METHODS: We utilized 8 synovial tissue RA datasets....

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