Statistical inference with large-scale trait imputation.

Abstract excerpt

Recently a nonparametric method called LS-imputation has been proposed for large-scale trait imputation based on a GWAS summary dataset and a large set of genotyped individuals. The imputed trait values, along with the genotypes, can be treated as an individual-level dataset for downstream genetic analyses, including those that cannot be done with GWAS summary data. However, since the covariance matrix of the...

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