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Gene therapy vector-related myocarditis

27 Nov 2023

Abstract excerpt

Gene therapy is a technique to correct genetic abnormalities, through introduction of a functional gene or through direct genome editing. Adeno-associated virus (AAV)-mediated gene replacement shows promise for targeted therapies in treatment of inherited cardiomyopathies and is the most used approach in clinical trials. However, immune responses from the host to the virus and gene product pose delivery and...

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PMID: 38030043
DOI: 10.1016/j.ijcard.2023.131617

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