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Article

Systematical assessment of the impact of single spike mutations of SARS-CoV-2 Omicron sub-variants on the neutralization capacity of post-vaccination sera.

Frontiers in immunology - 1 Jan 2023

Katzmarzyk Maeva, Clesle Denise Christine, van den Heuvel Joop, Hoffmann Markus, Garritsen Henk, Pöhlmann Stefan, Jacobsen Henning, Čičin-Šain Luka

Abstract excerpt

Introduction: The evolution of novel SARS-CoV-2 variants significantly affects vaccine effectiveness. While these effects can only be studied retrospectively, neutralizing antibody titers are most used as correlates of protection. However, studies assessing neutralizing antibody titers often show heterogeneous data. Methods: To address this, we investigated assay variance and identified virus infection time and...

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Identifiers

PMID: 38022629
DOI: 10.3389/fimmu.2023.1288794
PMCID: PMC10667444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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