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Article

Dysregulated Fatty Acid Metabolism in Preeclampsia Among Highland Andeans: Insights Into Adaptive and Maladaptive Placental Metabolic Phenotypes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 30 Nov 2025

O'Brien Katie A, Toledo-Jaldin Lilian, Gu Wanjun, Houck Julie A, Lazo-Vega Litzi, Miranda-Garrido Valquiria, Yung Hong W, Yasini Hussna, Moore Lorna G, Reisz Julie A, Simonson Tatum S, Shortt Jonathan, Stalker Margaret, D'Alessandro Angelo, Julian Colleen G

Abstract excerpt

High-altitude pregnancy presents the complex physiological challenge of fulfilling maternal, placental, and fetal metabolic demands under chronic ambient hypoxia. Highland Andeans exhibit signs of adaptation to high-altitude hypoxia, showing relative protection against altitude-associated fetal growth restriction (FGR) and the positive selection of metabolic genes linked to placental mitochondrial capacity. Not...

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Adaptation, Physiological
Altitude
Bolivia
Carnitine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fetal Growth Retardation

Source

Open in PubMed Open full text

Identifiers

PMID: 41273236
DOI: 10.1096/fj.202502590R
PMCID: PMC12639537

Genes

FGR
CPT2
EXOC4
LIPG
LRP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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