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Article

Detection of continuous hierarchical heterogeneity by single-cell surface antigen analysis in the prognosis evaluation of acute myeloid leukaemia.

BMC bioinformatics - 28 Nov 2023

Shao Nan, Ren Chenshuo, Hu Tianyuan, Wang Dianbing, Zhu Xiaofan, Li Min, Cheng Tao, Zhang Yingchi, Zhang Xian-En

Abstract excerpt

BACKGROUND: Acute myeloid leukaemia (AML) is characterised by the malignant accumulation of myeloid progenitors with a high recurrence rate after chemotherapy. Blasts (leukaemia cells) exhibit a complete myeloid differentiation hierarchy hiding a wide range of temporal information from initial to mature clones, including genesis, phenotypic transformation, and cell fate decisions, which might contribute to...

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Identifiers

PMID: 38017410
DOI: 10.1186/s12859-023-05561-0
PMCID: PMC10683216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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