Article
Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations.
Blood - 18 Nov 2010
Chou Wen-Chien, Huang Huai-Hsuan, Hou Hsin-An, Chen Chien-Yuan, Tang Jih-Luh, Yao Ming, Tsay Woei, Ko Bor-Sheng, Wu Shang-Ju, Huang Shang-Yi, Hsu Szu-Chun, Chen Yao-Chang, Huang Yen-Ning, Chang Yi-Chang, Lee Fen-Yu, Liu Min-Chih, Liu Chia-Wen, Tseng Mei-Hsuan, Huang Chi-Fei, Tien Hwei-Fang
Abstract excerpt
Mutations in the additional sex comb-like 1 (ASXL1) gene were recently shown in various myeloid malignancies, but they have not been comprehensively investigated in acute myeloid leukemia (AML). In this study, we analyzed ASXL1 mutations in exon 12 in 501 adults with de novo AML. ASXL1 mutations were detected in 54 patients (10.8%), 8.9% among those with normal karyotype and 12.9% among those with abnormal...
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