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Single Nucleotide Polymorphisms Mutation of Tropoelastin Gene Affects Tropoelastin mRNA and Elastin Expressions in Human Aortic Smooth Muscle Cells.

DNA and cell biology - 1 Dec 2023

Yue Jie, Qi You-Fei, Zhang Wen-Bo, Liu Sa-Hua, Chen Hao, Li Zhen-Zhen, Wu Hong-Fei

Abstract excerpt

We aimed to explore the effects of single nucleotide polymorphisms (SNPs) in tropoelastin gene on tropoelastin mRNA and elastin expressions in human aortic smooth muscle cells (HASMCs). Two SNP loci, rs2071307 (G/A) and rs1785598 (G/C), were selected to construct recombinant lentivirus vectors carrying wild-type and mutant tropoelastin gene. Recombinant plasmids including pWSLV-02-ELN, pWSLV-02-ELN-mut1, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38011321
DOI: 10.1089/dna.2023.0108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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