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Article

RIPK3 promotes brain region-specific interferon signaling and restriction of tick-borne flavivirus infection

27 Nov 2023

Abstract excerpt

Innate immune signaling in the central nervous system (CNS) exhibits many remarkable specializations that vary across cell types and CNS regions. In the setting of neuroinvasive flavivirus infection, neurons employ the immunologic kinase receptor-interacting kinase 3 (RIPK3) to promote an antiviral transcriptional program, independently of the traditional function of this enzyme in promoting necroptotic cell...

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PMID: 38011306
DOI: 10.1371/journal.ppat.1011813

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