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RIPK3 Promotes JEV Replication in Neurons via Downregulation of IFI44L

24 Mar 2020

Abstract excerpt

Japanese encephalitis virus (JEV), the leading cause of viral encephalitis in Asia, is neurovirulent and neuroinvasive. Neurons are the main target of JEV infection and propagation. Receptor interacting serine/threonine-protein kinase 3 (RIPK3) has been reported to contribute to neuroinflammation and neuronal death in many central nervous system diseases. In this study, we found that the progression of JE was...

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PMID: 32265853
DOI: 10.3389/fmicb.2020.00368

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