Article

Controlled cycling and quiescence enables homology directed repair in engraftment-enriched adult hematopoietic stem and progenitor cells

2018-04-13

Abstract excerpt

<h4>Summary</h4> Hematopoietic stem cells (HSCs) are the source of all blood components, and genetic defects in these cells are causative of disorders ranging from severe combined immunodeficiency to sickle cell disease. However, genome editing of long-term repopulating HSCs to correct mutated alleles has been challenging. HSCs have the ability to either be quiescent or cycle, with the former linked to stemness a...

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Literature Corpus work: 210f3a52-f5f8-5cd7-b624-6d4c65ffdbd4
DOI: 10.1101/301176

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