Article
ΔNp63α is a common inhibitory target in oncogenic PI3K/Ras/Her2-induced cell motility and tumor metastasis.
Proceedings of the National Academy of Sciences of the United States of America - 16 May 2017
Hu Linshan, Liang Shan, Chen Hu, Lv Tao, Wu Junfeng, Chen Deshi, Wu Min, Sun Shengnan, Zhang Haibo, You Han, Ji Hongbin, Zhang Yujun, Bergholz Johann, Xiao Zhi-Xiong Jim
Abstract excerpt
Activation of phosphatidylinositol 3 kinase (PI3K), Ras, and Her2 signaling plays a critical role in cancer development. Hotspot constitutive activating mutations in oncogenes, such as PIK3CA encoding the p110α catalytic subunit or RAS, as well as overexpression of Her2, are frequently found in human tumors and cancers. It has been well established that activation of these oncogenes profoundly promotes tumor...
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