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An Alport variant illuminates the bioactivity of the collagen IV <sup>α565-</sup> <sup>α121</sup> scaffold in Bowman’s capsule

2026-02-25

Abstract excerpt

Alport syndrome (AS) is a major cause of chronic kidney failure and affects millions of people worldwide. Pathogenic variants in COL4A3, COL4A4, and COL4A5, which encode the collagen IV α345 scaffold, compromise glomerular basement membrane (GBM) structure and function. However, the molecular mechanisms linking the >5,000 reported variants to disease pathology remain poorly understood. To address this gap, we pre...

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Literature Corpus work: efe666bc-9e08-52ac-906c-35197a970bb2
DOI: 10.64898/2026.02.23.707599

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