Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function

5 Aug 2021

Abstract excerpt

Autophagy degrades unnecessary proteins or damaged organelles to maintain cellular function. Therefore, autophagy has a preventive role against various diseases including hepatic disorders, neurodegenerative diseases, and cancer. Although autophagy in germ cells or Sertoli cells is known to be required for spermatogenesis and male fertility, it remains poorly understood how autophagy participates in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34351902
DOI: 10.1371/journal.pgen.1009688

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell functionPMID 34351902Read ↗

Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male miceSemantic proximity Read ↗

Autophagy: A Double-Edged Sword in Male ReproductionSemantic proximity Read ↗

Role of Selective Autophagy in Spermatogenesis and Male FertilitySemantic proximity Read ↗

Functional role of autophagy in testicular and ovarian steroidogenesisSemantic proximity Read ↗

Suppression of autophagic activity by Rubicon is a signature of agingSemantic proximity Read ↗

Deciphering the autophagy regulatory network via single-cell transcriptome analysis reveals a requirement for autophagy homeostasis in spermatogenesisSemantic proximity Read ↗

Autophagy core protein BECN1 is vital for spermatogenesis and male fertility in miceSemantic proximity Read ↗

Regulatory effects of autophagy on spermatogenesisSemantic proximity Read ↗

Role of Macroautophagy in Mammalian Male Reproductive PhysiologySemantic proximity Read ↗

Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of viewSemantic proximity Read ↗

Interplay of Oxidative Stress, Autophagy, and Rubicon in Ovarian Follicle Dynamics: Orchestrating Ovarian AgingSemantic proximity Read ↗

Interplay of Oxidative Stress, Autophagy, and Rubicon in Ovarian Follicle Dynamics: Orchestrating Ovarian AgingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.