Article
Modeling the effects of consanguinity on autosomal and X-chromosomal runs of homozygosity and identity-by-descent sharing.
G3 (Bethesda, Md.) - 7 Feb 2024
Cotter Daniel J, Severson Alissa L, Kang Jonathan T L, Godrej Hormazd N, Carmi Shai, Rosenberg Noah A
Abstract excerpt
Runs of homozygosity (ROH) and identity-by-descent (IBD) sharing can be studied in diploid coalescent models by noting that ROH and IBD-sharing at a genomic site are predicted to be inversely related to coalescence times-which in turn can be mathematically obtained in terms of parameters describing consanguinity rates. Comparing autosomal and X-chromosomal coalescent models, we consider ROH and IBD-sharing in...
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