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Article

Allele-specific long-range sequencing as a method for ABO haplotyping in clinical blood group diagnosis and immunohematology research.

Molecular genetics & genomic medicine - 1 Jan 2024

Matzhold Eva Maria, Drexler-Helmberg Camilla, Helmberg Wolfgang, Wagner Andrea, Wagner Thomas

Abstract excerpt

BACKGROUND: Safe transfusion therapy requires accurate testing of blood donors and recipients to determine their ABO blood group compatibility. Genotyping does not always clarify serological blood typing discrepancies and conventional PCR methods are not suitable to identify ABO haplotypes. Therefore, an allele-specific long-range sequencing-based typing method was established. METHODS: Study samples (n = 100)...

Topics

Humans
Alleles
Haplotypes
Genotype
Phenotype
ABO Blood-Group System

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37968878
DOI: 10.1002/mgg3.2286
PMCID: PMC10767447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-37968878-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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