Article
ABO genotyping with next-generation sequencing to resolve heterogeneity in donors with serology discrepancies.
Transfusion - 1 Sept 2018
Wu Ping Chun, Lin Yin-Hung, Tsai Lei Fang, Chen Ming Hung, Chen Pei-Lung, Pai Shun-Chung
Abstract excerpt
BACKGROUND: ABO subtypes are characterized by the alteration of antigens present and their expression levels on red blood cells and many are linked to genetic changes in the ABO gene. Weakened expression of antigens should be identified to prevent transfusion reactions or ABO-incompatible transplantations. Genotyping can be applied to identify subtypes to complement serologic testing. Next-generation sequencing...
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