Human leukocyte antigen-DQ risk heterodimeric haplotypes of left ventricular dysfunction in cardiac sarcoidosis: an autoimmune view of its role.

doi:10.1038/s41598-023-46915-1

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Article

Human leukocyte antigen-DQ risk heterodimeric haplotypes of left ventricular dysfunction in cardiac sarcoidosis: an autoimmune view of its role.

Scientific reports - 13 Nov 2023

Yamamoto Hironori, Miyashita Yohei, Minamiguchi Hitoshi, Hosomichi Kazuyoshi, Yoshida Shohei, Kioka Hidetaka, Shinomiya Haruki, Nagata Haruno, Onoue Kenji, Kawasaki Masato, Kuramoto Yuki, Nomura Akihiro, Toma Yuichiro, Watanabe Tetsuya, Yamada Takahisa, Ishihara Yasuki, Nagata Miho, Kato Hisakazu, Hakui Hideyuki, Saito Yoshihiko, Asano Yoshihiro, Sakata Yasushi

Abstract excerpt

Cardiac sarcoidosis (CS) is the scarring of heart muscles by autoimmunity, leading to heart abnormalities and patients with sarcoidosis with cardiac involvements have poor prognoses. Due to the small number of patients, it is difficult to stratify all patients of CS by human leukocyte antigen (HLA) analysis. We focused on the structure of antigen-recognizing pockets in heterodimeric HLA-class II, in addition to...

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PMID: 37957180
DOI: 10.1038/s41598-023-46915-1
PMCID: PMC10643531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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