Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health.

doi:10.1038/s41380-025-03356-8

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Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health.

Molecular psychiatry - 1 Apr 2026

Thorpe Hayley H A, Cupertino Renata B, Pakala Shreya Reddy, Fontanillas Pierre, Jennings Mariela V, Yang Jane, Meredith John J, Greenwood Tiffany, Bianchi Sevim B, Vilar-Ribó Laura, Niarchou Maria, Elson Sarah L, Ideker Trey, Davis Lea K, MacKillop James, deWit Harriet, Gustavson Daniel E, Mallard Travis T, Palmer Abraham A, Sanchez-Roige Sandra

Abstract excerpt

Delay discounting (DD), a person's preference for smaller immediate rewards over larger delayed rewards, is a heritable trait that is associated with psychiatric and physical outcomes, yet the biological mechanisms underlying these links are not known. We performed a GWAS of DD using 134,935 23andMe research participants and identified 11 genome-wide significant loci. We did not replicate our previously reported...

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PMID: 41286433
DOI: 10.1038/s41380-025-03356-8
PMCID: PMC12999501

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GPM6B

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