Article
Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation.
Cell reports - 28 Nov 2023
Ge Zehe, Xu Miao, Ge Yuqian, Huang Guang, Chen Dongyin, Ye Xiuquan, Xiao Yibei, Zhu Hongyu, Yin Rong, Shen Hua, Ma Gaoxiang, Qi Lianwen, Wei Guining, Li Dongmei, Wei Shaofeng, Zhu Meng, Ma Hongxia, Shi Zhumei, Wang Xiuxing, Ge Xin, Qian Xu
Abstract excerpt
EGFRT790M mutation causes resistance to the first-generation tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancer (NSCLC). However, the therapeutic options for sensitizing first TKIs and delaying the emergence of EGFRT790M mutant are limited. In this study, we show that quercetin directly binds with glucose-6-phosphate dehydrogenase (G6PD) and inhibits its enzymatic activity through...
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