Comparative thrombotic risk associated with CALR1 , CALR2 , and JAK2 V617F mutations in essential thrombocythemia

Abstract excerpt

Thrombosis is a common complication of Essential Thrombocythemia (ET) and is responsible for significant morbidity and mortality in affected individuals. The JAK2 V617F mutation is a well-established risk factor for thrombosis in ET, with a reported prevalence of approximately 50% in patients with ET. However, there is increasing evidence that other mutations, including CALR mutations, also independently confer...

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