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Article

Hematological relevance of JAK2 V617F and calreticulin mutations in Tunisian patients with essential thrombocythemia.

Journal of clinical laboratory analysis - 1 Aug 2022

Abdelghani Maroua, Hammami Haifa, Zidi Wiem, Amouri Hassiba, Othmen Hind Ben Hadj, Farrah Ahlem, Menif Samia

Abstract excerpt

BACKGROUND: The genetic investigation of essential thrombocythemia(ET) has highlighted the presence of driver mutations in ET. Janus kinase JAK2V617F and calreticulin(CALR) mutations are the most frequent driver mutations and have significantly improved the molecular diagnosis of ET. The impact of genetic heterogeneity on clinical features has not been fully elucidated. This is the first study which aimed to...

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Calreticulin
Janus Kinase 2
Mutation
Thrombocythemia, Essential
Thrombosis

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PMID: 35754115
DOI: 10.1002/jcla.24522
PMCID: PMC9396186

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Hematological relevance of JAK2 V617F and calreticulin mutations in Tunisian patients with essential thrombocythemia.PMID 35754115Read ↗

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