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Article

Effect of prothrombin Belgrade mutation, causing antithrombin resistance, on fibrin clot properties.

International journal of laboratory hematology - 1 Apr 2024

Dunjic Manevski Sofija, Cumbo Marija, Pruner Iva, Gvozdenov Maja, Tomic Branko, Taxiarchis Apostolos, Antovic Jovan, Djordjevic Valentina

Abstract excerpt

INTRODUCTION: Prothrombin Belgrade mutation is the result of the c.1787G>A substitution in the prothrombin gene. It is located in the antithrombin and sodium binding site and leads to impaired inactivation of thrombin by antithrombin, resulting in antithrombin resistance and thrombotic disorders. However, it negatively affects sodium binding and may have hypocoagulant effects. Considering that prothrombin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37918971
DOI: 10.1111/ijlh.14195

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