Article
[The effect of FII c.1787G>A (prothrombin Belgrade) mutation on prothrombin gene expression in vitro].
Molekuliarnaia biologiia - 1 Jan 2000
Gvozdenov M, Pruner I, Tomic B, Kovac M, Radojkovic D, Djordjevic V
Abstract excerpt
The FII c.1787G>A (prothrombin Belgrade) is a novel prothrombotic mutation which leads to impaired inhibition of thrombin by antithrombin (antithrombin resistance). So far, the mechanism of this variant has not been fully elucidated. To investigate the effect of FII c.1787G>A mutation on the prothrombin gene expression, its functional analysis was performed in vitro. By Real-Time PCR, expression levels of FII...
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