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Evaluation of ADRB2 and OATP2A1 genetic polymorphisms in Indian patients with primary open-angle glaucoma.

Pharmacogenetics and genomics - 1 Jan 2024

Gowtham Lakshminarayanan, Halder Nabanita, Singh Sundararajan Baskar, Angmo Dewang, Jayasundar Rama, Dada Tanuj, Velpandian Thirumurthy

Abstract excerpt

The emergence of adrenergic β2-receptor (ADRB2) blockers has revolutionized glaucoma treatment, while the discovery of prostaglandin analogs has further expanded therapeutic options. Organic anion transporting polypeptide 2A1 (OATP2A1/SLCO2A1) facilitates the corneal transport of topical prostaglandins into anterior segment of eye. Our study aims to elucidate the prevalence of genetic polymorphisms in the ADRB2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37906648
DOI: 10.1097/FPC.0000000000000512

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