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Article

PTPN13 Participates in the Regulation of Epithelial-Mesenchymal Transition and Platinum Sensitivity in High-Grade Serous Ovarian Carcinoma Cells.

International journal of molecular sciences - 21 Oct 2023

Aptecar Leticia, Puech Carole, Lopez-Crapez Evelyne, Peter Marion, Coopman Peter, D'Hondt Véronique, Freiss Gilles

Abstract excerpt

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological cancers in Western countries. High-Grade Serous Ovarian Carcinoma (HGSOC) accounts for 60-70% of EOC and is the most aggressive subtype. Reduced PTPN13 expression levels have been previously correlated with worse prognosis in HGSOC. However, PTPN13's exact role and mechanism of action in these tumors remained to be investigated. To...

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Share to Carcinoma, Ovarian Epithelial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37895093
DOI: 10.3390/ijms242015413
PMCID: PMC10607604

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