Article
Assessment of intestinal status in MPLW515L mutant myeloproliferative neoplasms mice model.
International immunopharmacology - 1 Dec 2023
Zhu Shengyun, Xu Kairen, Li Shuyao, Yu Xiangru, Liu Yahui, Zhang Qigang, Zeng Lingyu, Xu Kailin, Fu Chunling
Abstract excerpt
The MPLW515L mutation is a prevalent genetic mutation in patients with myeloproliferative neoplasms (MPN), and utilizing this mutation in mice model can provide important insights into the disease. However, the relationship between intestinal homeostasis and MPN mice model remains elusive. In this study, we utilized a retroviral vector to transfect hematopoietic stem cells with the MPLW515L mutation, creating...
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