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Article

Evaluation of virulent and live Shigella sonnei vaccine candidates in a gnotobiotic piglet model.

Vaccine - 20 Aug 2013

Jeong Kwang-Il, Venkatesan Malabi M, Barnoy Shoshana, Tzipori Saul

Abstract excerpt

Newborn gnotobiotic (GB) piglets given virulent Shigella orally develop many of the clinical symptoms and gastrointestinal (GI) manifestations that mimic human shigellosis. Shigella sonnei virulent strain Moseley, a mutant ShET2-1,2, lacking enterotoxin SenA and its paralog SenB, and vaccine candidates WRSS1 and WRSs3 were evaluated in this model for rates of diarrhea, colonization and other GI symptoms and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23684833
DOI: 10.1016/j.vaccine.2013.04.076

Genes

PID1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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