Article
Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci.
PLoS genetics - 1 Oct 2023
Pasanen Anu, Karjalainen Minna K, Zhang Ge, Tiensuu Heli, Haapalainen Antti M, Ojaniemi Marja, Feenstra Bjarke, Jacobsson Bo, Palotie Aarno, Laivuori Hannele, Muglia Louis J, Rämet Mika, Hallman Mikko
Abstract excerpt
BACKGROUND: Preterm birth (<37 weeks of gestation) is a major cause of neonatal death and morbidity. Up to 40% of the variation in timing of birth results from genetic factors, mostly due to the maternal genome. METHODS: We conducted a genome-wide meta-analysis of gestational duration and spontaneous preterm birth in 68,732 and 98,370 European mothers, respectively. RESULTS: The meta-analysis detected 15 loci...
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