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Article

CCDC66 mutations are associated with high myopia through affected cell mitosis.

Journal of medical genetics - 21 Feb 2024

Chen Xiaozhen, Tong Ping, Jiang Ying, Cheng Zhe, Zang Liyu, Yang Zhikuan, Lan Weizhong, Xia Kun, Hu Zhengmao, Tian Qi

Abstract excerpt

BACKGROUND: High myopia (HM) refers to an eye refractive error exceeding -5.00 D, significantly elevating blindness risk. The underlying mechanism of HM remains elusive. Given the extensive genetic heterogeneity and vast genetic base opacity, it is imperative to identify more causative genes and explore their pathogenic roles in HM. METHODS: We employed exome sequencing to pinpoint the causal gene in an HM...

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PMID: 37852749
DOI: 10.1136/jmg-2023-109434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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