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Article

Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer's phenotypes without blocking peripheral T cell IL-2 response.

Alzheimer's research & therapy - 17 Oct 2023

Stallings Nancy R, O'Neal Melissa A, Hu Jie, Shen Zhong-Jian, Malter James S

Abstract excerpt

BACKGROUND: Current treatments for Alzheimer's disease (AD) have largely failed to yield significant therapeutic benefits. Novel approaches are desperately needed to help address this immense public health issue. Data suggests that early intervention at the first stages of mild cognitive impairment may have a greater chance for success. The calcineurin (CN)-Pin1 signaling cascade can be selectively targeted with...

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Identifiers

PMID: 37849016
DOI: 10.1186/s13195-023-01323-5
PMCID: PMC10580561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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