Article

An intratumorally discovered extracellular vesicle-derived biomarker enables ultrasensitive digital quantification in plasma for early detection of non-small cell lung cancer

2025-06-11

Abstract excerpt

<h4>Background</h4> Extracellular vesicle (EV)-based liquid biopsy remains challenging due to the limited specificity and low abundance of EV cargoes. This study aimed to identify cancer-specific molecules from tissue-derived EVs and evaluate their potential as circulating biomarkers for non-small cell lung cancer (NSCLC). <h4>Methods</h4> Tissue-derived EVs were isolated by density gradient flotation and subjecte...

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Literature Corpus work: 6d70699e-2171-505d-8b20-bdce218ba95f
DOI: 10.1101/2025.06.09.25329294

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