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Article

Cationic Polymers Remarkably Boost Haloalkane Dehalogenase Activity in Organic Solvent Solutions and the Molecular Implications.

Molecules (Basel, Switzerland) - 25 Sept 2023

Wu Yin, Sun Yan

Abstract excerpt

Applications of haloalkane dehalogenase DhaA in biocatalysis are limited by its unfavorable performance in organic solvents. Our previous work proved that mutations of surface positive-charged residues enhanced the organic solvent resistance of DhaA, which inspired us to explore the effect of cationic polymers on DhaA in organic solvents. Remarkably boosted performance was achieved in different organic solvent...

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PMID: 37836637
DOI: 10.3390/molecules28196795
PMCID: PMC10574148

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