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Article

Characterization and engineering of a two-enzyme system for plastics depolymerization.

Proceedings of the National Academy of Sciences of the United States of America - 13 Oct 2020

Knott Brandon C, Erickson Erika, Allen Mark D, Gado Japheth E, Graham Rosie, Kearns Fiona L, Pardo Isabel, Topuzlu Ece, Anderson Jared J, Austin Harry P, Dominick Graham, Johnson Christopher W, Rorrer Nicholas A, Szostkiewicz Caralyn J, Copié Valérie, Payne Christina M, Woodcock H Lee, Donohoe Bryon S, Beckham Gregg T, McGeehan John E

Abstract excerpt

Plastics pollution represents a global environmental crisis. In response, microbes are evolving the capacity to utilize synthetic polymers as carbon and energy sources. Recently, Ideonella sakaiensis was reported to secrete a two-enzyme system to deconstruct polyethylene terephthalate (PET) to its constituent monomers. Specifically, the I. sakaiensis PETase depolymerizes PET, liberating soluble products,...

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PMID: 32989159
DOI: 10.1073/pnas.2006753117
PMCID: PMC7568301

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