Article
Single-Cell Profiling of Cells in the Lung of a Patient with Chronic Hypersensitivity Pneumonitis Reveals Inflammatory Niche with Abundant CD39+ T Cells with Functional ATPase Phenotype: A Case Study.
International journal of molecular sciences - 22 Sept 2023
de Silva Tharushi Ayanthika, Apte Simon, Voisey Joanne, Spann Kirsten, Tan Maxine, Divithotawela Chandima, Chambers Daniel, O'Sullivan Brendan
Abstract excerpt
This study investigated immune cell characteristics in chronic hypersensitivity pneumonitis (HP), focusing on CD39-expressing cells' impact on inflammation and tissue remodelling. Lung tissue from an HP patient was analysed using single-cell transcriptomics, flow cytometry, and gene expression profiling. The tissue revealed diverse cell types like macrophages, T cells, fibroblasts, and regulatory T cells (Tregs)....
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