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Article

A novel rare variants association test for binary traits in family-based designs via copulas.

Statistical methods in medical research - 1 Nov 2023

Dossa Houssou R G, Bureau Alexandre, Maziade Michel, Lakhal-Chaieb Lajmi, Oualkacha Karim

Abstract excerpt

With the cost-effectiveness technology in whole-genome sequencing, more sophisticated statistical methods for testing genetic association with both rare and common variants are being investigated to identify the genetic variation between individuals. Several methods which group variants, also called gene-based approaches, are developed. For instance, advanced extensions of the sequence kernel association test,...

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PMID: 37832140
DOI: 10.1177/09622802231197977
PMCID: PMC10683345

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