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Article

An Integrative Approach to Lung Cancer Therapy: Linking the TGF-β (+869 C/T) Polymorphism to a Structurally Validated Natural Inhibitor.

Asian Pacific journal of cancer prevention : APJCP - 1 Apr 2026

Abdulsahib Nawar Bahaa, Hameed Mohammed A, Yousif Ragheed Hussam, Jabir Majid Sakhi

Abstract excerpt

OBJECTIVE: This study aimed to create a genetic and clinical roadmap for the TGF-β pathway in an Iraqi population, focusing on the TGF-β1 (+869 C/T) polymorphism. METHODS: A structure-guided approach was used to identify a natural compound, quercetin, as a potential inhibitor of its primary receptor, ALK5. The clinical aspect evaluated the biochemical profile of each patient by measuring serum levels of TGF-β and...

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PMID: 41945959
DOI: 10.31557/APJCP.2026.27.4.1421

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