Article
Genetic Evidence for Causal Effects of Domain-Specific Physical Activity and Sedentary Behavior on Osteoporosis and Inflammatory Arthritis: A Bidirectional Mendelian Randomization Study.
Genes - 12 Aug 2026
Sun Tianyu, Zhang Feiyao, Liu Chang, Huang Junhao
Abstract excerpt
OBJECTIVE: Genetic factors contribute to physical activity (PA) and sedentary behavior (SB), two complex behavioral traits. They may be associated with musculoskeletal and inflammatory diseases. However, the relationships of domain-specific PA and SB traits with osteoporosis (OS), psoriatic arthritis (PsA), and rheumatoid arthritis (RA) remain unclear. A two-sample Mendelian randomization (MR) analysis assessed...
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