Seneca valley virus activates autophagy through the PERK and ATF6 UPR pathways

Abstract excerpt

Diverse effects on autophagy, a cell degradation pathway, have been associated with the infectious mechanisms of different pathogens. Here, we demonstrated that Seneca valley virus (SVV), an important emerging porcine virus characterized by vesicular lesions and neonatal mortality, can induce autophagy in cultured PK-15 and BHK-21 cells by detecting autophagosome formation, GFP-LC3 puncta and accumulation of...

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• Autophagy in Disease and Therapy
• Endoplasmic Reticulum Stress and Disease
• Mosquito-borne diseases and control