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Article

The mitochondrial negative regulator MCJ modulates the interplay between microbiota and the host during ulcerative colitis

17 Jan 2020

Abstract excerpt

Recent evidences indicate that mitochondrial genes and function are decreased in active ulcerative colitis (UC) patients, in particular, the activity of Complex I of the electron transport chain is heavily compromised. MCJ is a mitochondrial inner membrane protein identified as a natural inhibitor of respiratory chain Complex I. The induction of experimental colitis in MCJ-deficient mice leads to the upregulation...

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PMID: 31953445
DOI: 10.1038/s41598-019-57348-0

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