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Lactate promotes Salmonella intracellular replication and systemic infection via driving macrophage M2 polarization

5 Oct 2023

Abstract excerpt

ABSTRACT Salmonella is one of the most important enteric pathogens worldwide, which is able to cause lethal systemic infection via survival and replication in host macrophages. Lactate, a byproduct of anaerobic or aerobic glycolysis, can induce macrophage M2 polarization, but the relationship between lactate-mediated macrophage M2 polarization and bacterial infection is poorly understood. Here, we evaluated the...

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PMID: 37796020
DOI: 10.1128/spectrum.02253-23

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