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Article

Alternative splicing in lung influences COVID-19 severity and respiratory diseases.

Nature communications - 4 Oct 2023

Nakanishi Tomoko, Willett Julian, Farjoun Yossi, Allen Richard J, Guillen-Guio Beatriz, Adra Darin, Zhou Sirui, Richards J Brent

Abstract excerpt

Alternative splicing generates functional diversity in isoforms, impacting immune response to infection. Here, we evaluate the causal role of alternative splicing in COVID-19 severity and susceptibility by applying two-sample Mendelian randomization to cis-splicing quantitative trait loci and the results from COVID-19 Host Genetics Initiative. We identify that alternative splicing in lung, rather than total...

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Identifiers

PMID: 37794074
DOI: 10.1038/s41467-023-41912-4
PMCID: PMC10550956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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