Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis

3 Oct 2023

Abstract excerpt

The functional integrity of Tregs is interwoven with cellular metabolism; however, the mechanisms governing Treg metabolic programs remain elusive. Here, we identified that the deubiquitinase USP47 inhibited c-Myc translation mediated by the RNA N6-methyladenosine (m6A) reader YTHDF1 to maintain Treg metabolic and functional homeostasis. USP47 positively correlated with the tumor-infiltrating Treg signature in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to RNA modifications and cancer
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37788092
DOI: 10.1172/jci169365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasisPMID 37788092Read ↗

USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylationSemantic proximity Read ↗

Role of Ubiquitin-Specific Peptidase 47 in Cancers and Other DiseasesSemantic proximity Read ↗

SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinomaSemantic proximity Read ↗

System-wide identification of novel de-ubiquitination targets for USP10 in gastric cancer metastasis through multi-omics screeningSemantic proximity Read ↗

USP30 inhibition augments mitophagy to prevent T cell exhaustionSemantic proximity Read ↗

MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment.Semantic proximity Read ↗

FTO O-GlcNAcylation downregulates NLRP3 inflammasome and pyroptosis in macrophagesSemantic proximity Read ↗

YTHDC1 inhibits autophagy-dependent NF-κB signaling by stabilizing Beclin1 mRNA in macrophagesSemantic proximity Read ↗

USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor FormationSemantic proximity Read ↗

USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancerSemantic proximity Read ↗

USP14-mediated deubiquitination of SIRT1 in macrophage promotes fatty acid oxidation amplification and M2 phenotype polarization.Semantic proximity Read ↗

USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitinationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.