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Article

Proximity Proteomics Revealed Aberrant mRNA Splicing Elicited by ALS-Linked Profilin-1 Mutants.

Analytical chemistry - 17 Oct 2023

Wei Songbo, Yang YenYu, Wang Yinsheng

Abstract excerpt

Profilin 1 (PFN1) is a cytoskeleton protein that modulates actin dynamics through binding to monomeric actin and polyproline-containing proteins. Mutations in PFN1 have been linked to the pathogenesis of familial amyotrophic lateral sclerosis (ALS). Here, we employed an unbiased proximity labeling strategy in combination with proteomic analysis for proteome-wide profiling of proteins that differentially interact...

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Identifiers

PMID: 37787459
DOI: 10.1021/acs.analchem.3c03734
PMCID: PMC10689300

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