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Article

A Metabolomics Analysis of a Novel Phenotype of Older Adults at Higher Risk of Dementia.

Journal of Alzheimer's disease : JAD - 1 Jan 2024

Sultana Munira, Camicioli Richard, Dixon Roger A, Whitehead Shawn, Pieruccini-Faria Frederico, Petrotchenko Evgeniy, Speechley Mark, Borchers Christoph H, Montero-Odasso Manuel

Abstract excerpt

Background: Older adults presenting with dual-decline in cognition and walking speed face a 6-fold higher risk for dementia compared with those showing no decline. We hypothesized that the metabolomics profile of dual-decliners would be unique even before they show signs of decline in cognition and gait speed. Objective: The objective of this study was to determine if plasma metabolomics signatures can...

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Identifiers

PMID: 37781807
DOI: 10.3233/JAD-230683

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