Article
Heritable Composite Phenotypes Defined by Combinations of Conduct Problem, Depression, and Temperament Features: Contributions to risk for Alcohol Problems.
Research on child and adolescent psychopathology - 1 Apr 2024
Wang Frances L, Klei Lambertus, Devlin Bernie, Molina Brooke S G, Chassin Laurie
Abstract excerpt
The genetic architectures underlying symptoms of conduct problems and depression have largely been examined separately and without incorporating temperament, despite evidence for their genetic overlap. We examined how symptoms and temperament dimensions were transmitted together in families to identify highly heritable composite phenotypes, and how these composite phenotypes predicted alcohol outcomes in young...
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